Portability, integration with web in any shape, manner and form
unless they are overall really right there in the mix, with their own advantages.
I'm sure there are probably 5-10 other similars worthy of consideration, lets not include them other than en passant notice. Keynotes-NF is the open source followup to Keynote, when I use TreeDBNotes I must admit the interface is rather a bit more pleasant (a real factor in note programs) and AllMyNotes Organizer looks like the new kid on the block, with a DC discount and perhaps the most active development ? Here I would like to limit the discussion to the basic motif - a tree-style (often with tabs) note program. We have had incredible threads on note-taking concepts as a whole.